Chemical-specific adjustment factors for interspecies differences and human variability : guidance document for use of data in dose/concentration-response assessment / IPCS, International Programme on Chemical Safety, IOMC, Inter-Organization Programme for the Sound Management of Chemicals
By: IPCS - International Programme on Chemical Safety
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Contributor(s): WHO - World Health Organization | IOMC - Inter-Organization Programme for the Sound Management of Chemicals | Programa Internacional Sobre Seguridad de los Productos Químicos | OMS - Organización Mundial de la Salud (Ginebra) | IPCS Workshop on Incorporating Uncertainty and Variability into Risk Assessment (2000 : Berlin, Germany).
Series: IPCS - harmonization project document no. 2.Geneva : World Health Organization, 2005 Description: iii, 96 p.ISBN: 92-4-154678-6 -- 978-92-4-154678-2.Subject(s): Productos químicos | Toxicidad de los productos químicos | Efectos nocivos | Variación (genética) | Especificidad de la especie | Estándares del gravamen de riesgo | Salud | MedicinaDDC classification: 615.902 / Hp002 Acceso electrónico: http://whqlibdoc.who.int/publications/2005/9241546786_eng.pdf| Item type | Current location | Collection | Call number | Vol info | Copy number | Status | Notes | Date due | Barcode | Item holds |
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Biblioteca Ciencias de la Salud | FONDO BIBL | 615.902 / Hp002 (Browse shelf) | 8001 | 1 | Available | DO | 8300004507 |
Published under the joint sponsorship of the United Nations Environment Programme, the International Labour
Organization, and the World Health Organization, and produced within the framework of the Inter-Organizational
Programme for the Sound Management of Chemicals. Publicado bajo patrocinio común del programa del
ambiente de Naciones Unidas, de la organización de trabajo internacional, y de la Organización Mundial de la
Salud, y producido en el marco del programa interorganizacional para la gerencia sana de productos químicos.
Introduction: Objetives -- Chemical-specific adjustment factors and risk assessment -- Background --
Framework for development of chemical-specific adjustment factors -- Development of default subfactors for
toxicokinetic and toxicodynamic aspects -- Separation of the overall process producing toxicity into
toxicokinetics and toxicodynamics within the context of chemical-specific adjustment factors -- Calculacion of
the composite uncertainty factor -- Guidance for the use of data in development of chemical specific
adjustment factors for interpecies differences and human variability -- Data for the development of a
chemical-specific adjustment factor for interspecies differences in toxicokinetics (AKaf) -- Data for the
development of a chemical-specific adjustment factor for interspecies differences in toxicodynamics (ADaf) --
Data for the development of a chemical-specific adjustment factor for human variability in toxicokinetics
(HKaf) -- Data for the development of a chemical-specifric adjustment factor for human variability in
toxicodynamics (ADaf) -- References -- Case-studies -- Glossary of terms --
Existe también en medio magnético en la Biblioteca Electrónica de la Facultad de Salud
Acceso electrónico: http://whqlibdoc.who.int/publications/2005/9241546786_eng.pdf
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