Chemical-specific adjustment factors for interspecies differences and human variability : guidance document for use of data in dose/concentration-response assessment / IPCS, International Programme on Chemical Safety, IOMC, Inter-Organization Programme for the Sound Management of Chemicals
- iii, 96 p.
- IPCS - harmonization project document no. 2 .
Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organizational Programme for the Sound Management of Chemicals. Publicado bajo patrocinio común del programa del ambiente de Naciones Unidas, de la organización de trabajo internacional, y de la Organización Mundial de la Salud, y producido en el marco del programa interorganizacional para la gerencia sana de productos químicos.
Introduction: Objetives -- Chemical-specific adjustment factors and risk assessment -- Background -- Framework for development of chemical-specific adjustment factors -- Development of default subfactors for toxicokinetic and toxicodynamic aspects -- Separation of the overall process producing toxicity into toxicokinetics and toxicodynamics within the context of chemical-specific adjustment factors -- Calculacion of the composite uncertainty factor -- Guidance for the use of data in development of chemical specific adjustment factors for interpecies differences and human variability -- Data for the development of a chemical-specific adjustment factor for interspecies differences in toxicokinetics (AKaf) -- Data for the development of a chemical-specific adjustment factor for interspecies differences in toxicodynamics (ADaf) -- Data for the development of a chemical-specific adjustment factor for human variability in toxicokinetics (HKaf) -- Data for the development of a chemical-specifric adjustment factor for human variability in toxicodynamics (ADaf) -- References -- Case-studies -- Glossary of terms --
Existe también en medio magnético en la Biblioteca Electrónica de la Facultad de Salud
92-4-154678-6 -- 978-92-4-154678-2
Productos químicos
Toxicidad de los productos químicos
Efectos nocivos
Variación (genética)
Especificidad de la especie
Estándares del gravamen de riesgo
Salud
Medicina
615.902 / Hp002
Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organizational Programme for the Sound Management of Chemicals. Publicado bajo patrocinio común del programa del ambiente de Naciones Unidas, de la organización de trabajo internacional, y de la Organización Mundial de la Salud, y producido en el marco del programa interorganizacional para la gerencia sana de productos químicos.
Introduction: Objetives -- Chemical-specific adjustment factors and risk assessment -- Background -- Framework for development of chemical-specific adjustment factors -- Development of default subfactors for toxicokinetic and toxicodynamic aspects -- Separation of the overall process producing toxicity into toxicokinetics and toxicodynamics within the context of chemical-specific adjustment factors -- Calculacion of the composite uncertainty factor -- Guidance for the use of data in development of chemical specific adjustment factors for interpecies differences and human variability -- Data for the development of a chemical-specific adjustment factor for interspecies differences in toxicokinetics (AKaf) -- Data for the development of a chemical-specific adjustment factor for interspecies differences in toxicodynamics (ADaf) -- Data for the development of a chemical-specific adjustment factor for human variability in toxicokinetics (HKaf) -- Data for the development of a chemical-specifric adjustment factor for human variability in toxicodynamics (ADaf) -- References -- Case-studies -- Glossary of terms --
Existe también en medio magnético en la Biblioteca Electrónica de la Facultad de Salud
92-4-154678-6 -- 978-92-4-154678-2
Productos químicos
Toxicidad de los productos químicos
Efectos nocivos
Variación (genética)
Especificidad de la especie
Estándares del gravamen de riesgo
Salud
Medicina
615.902 / Hp002