| 000 | 03757nam a22005417a 4500 | ||
|---|---|---|---|
| 008 | 140202b ck ||||| |||| 00| 0 spa d | ||
| 020 | _a92-4-154678-6 -- 978-92-4-154678-2 | ||
| 082 | 0 | 4 | _a615.902 / Hp002 |
| 110 | 1 |
_aIPCS - International Programme on Chemical Safety _993287 |
|
| 245 | 1 | 0 | _aChemical-specific adjustment factors for interspecies differences and human variability : guidance document |
| 245 | 1 | 0 | _afor use of data in dose/concentration-response assessment / IPCS, International Programme on Chemical Safety, |
| 245 | 1 | 0 | _aIOMC, Inter-Organization Programme for the Sound Management of Chemicals |
| 264 | _aGeneva : World Health Organization, 2005 | ||
| 300 | _aiii, 96 p. | ||
| 490 | 0 |
_aIPCS - harmonization project document _vno. 2 _997281 |
|
| 500 | _aPublished under the joint sponsorship of the United Nations Environment Programme, the International Labour | ||
| 500 | _aOrganization, and the World Health Organization, and produced within the framework of the Inter-Organizational | ||
| 500 | _aProgramme for the Sound Management of Chemicals. Publicado bajo patrocinio común del programa del | ||
| 500 | _aambiente de Naciones Unidas, de la organización de trabajo internacional, y de la Organización Mundial de la | ||
| 500 | _aSalud, y producido en el marco del programa interorganizacional para la gerencia sana de productos químicos. | ||
| 505 | 0 | 0 | _aIntroduction: Objetives -- Chemical-specific adjustment factors and risk assessment -- Background -- |
| 505 | 0 | 0 | _aFramework for development of chemical-specific adjustment factors -- Development of default subfactors for |
| 505 | 0 | 0 | _atoxicokinetic and toxicodynamic aspects -- Separation of the overall process producing toxicity into |
| 505 | 0 | 0 | _atoxicokinetics and toxicodynamics within the context of chemical-specific adjustment factors -- Calculacion of |
| 505 | 0 | 0 | _athe composite uncertainty factor -- Guidance for the use of data in development of chemical specific |
| 505 | 0 | 0 | _aadjustment factors for interpecies differences and human variability -- Data for the development of a |
| 505 | 0 | 0 | _achemical-specific adjustment factor for interspecies differences in toxicokinetics (AKaf) -- Data for the |
| 505 | 0 | 0 | _adevelopment of a chemical-specific adjustment factor for interspecies differences in toxicodynamics (ADaf) -- |
| 505 | 0 | 0 | _aData for the development of a chemical-specific adjustment factor for human variability in toxicokinetics |
| 505 | 0 | 0 | _a(HKaf) -- Data for the development of a chemical-specifric adjustment factor for human variability in |
| 505 | 0 | 0 | _atoxicodynamics (ADaf) -- References -- Case-studies -- Glossary of terms -- |
| 521 | _aExiste también en medio magnético en la Biblioteca Electrónica de la Facultad de Salud | ||
| 530 | _aAcceso electrónico: http://whqlibdoc.who.int/publications/2005/9241546786_eng.pdf | ||
| 650 | 1 | 4 |
_aProductos químicos _9128845 |
| 650 | 1 | 4 |
_aToxicidad de los productos químicos _9133462 |
| 650 | 1 | 4 |
_aEfectos nocivos _9107906 |
| 650 | 1 | 4 |
_aVariación (genética) _9134385 |
| 650 | 1 | 4 |
_aEspecificidad de la especie _9109423 |
| 650 | 1 | 4 |
_aEstándares del gravamen de riesgo _9109596 |
| 650 | 1 | 4 |
_aSalud _9130891 |
| 650 | 1 | 4 |
_aMedicina _9115965 |
| 710 | 1 |
_aWHO - World Health Organization _994155 |
|
| 710 | 1 |
_aIOMC - Inter-Organization Programme for the Sound Management of Chemicals _993285 |
|
| 710 | 1 |
_aPrograma Internacional Sobre Seguridad de los Productos Químicos _993581 |
|
| 710 | 1 |
_aOMS - Organización Mundial de la Salud (Ginebra) _993454 |
|
| 711 |
_aIPCS Workshop on Incorporating Uncertainty and Variability into Risk Assessment (2000 : Berlin, Germany) _994326 |
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| 999 |
_c24937 _d24937 |
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