Environmental health criteria for transgenic animal mutagenicity assays -- Acronyms and abbreviations --

Glossary -- Summary -- Overview of genotoxicity testing and transgenic animal mutagenicity systems -- Overview

of genotoxicity testing -- Construction/production of transgenic animals using as examples the laci and lacz

mutation models -- The transgenic mutagenicity assay - methodology using as examples laci and lacz mutation

models -- Further transgenic mutagenicity assays -- Parameters and criteria for valid experimental design --

Comparison of the laci model and the lacz model with conventional test systems -- Comparison of the muta Tm

Mouse and Big Blue assays -- Transgenic assays - comparison with other assays --Transgenic assays and

carcinogenicity testing -- Applications of transgenic animal mutagenicity studies -- Mutation frequencies and

sequencing data and applications of this information in mechanistc studies -- Evaluation, conclusions and

recommendations -- Evaluation of the transgenic animal mutagenicity assays based on this review of the current

literature -- Appendiz - Master table -- The CII assay in transgenic rodenst studies -- Resume -- Resumen --

This report contains the conllective views of an international group of experts and does not necessarily

represent the decisions or the stated policy of the United Nations Environment Programme, the International

Labour Organization or the World Health Organization.

los profanos en el campo de las valoraciones de la mutagenicidad transgenica y evaluar su posible función en

las pruebas de toxicología y la investigación mecanicista.